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An independent data and protection monitoring committee reviewed the safety data. The decision to send the manuscript for publication was created by all the authors and the sponsor, which retains the data. All of the authors had usage of all analyses, wrote the first draft of the manuscript, and approved the ultimate manuscript. Alexion Pharmaceuticals and Infusion Communications provided medical-writing support. The studies and informed-consent process were approved by the institutional review board at each center or by an independent ethics committee and were conducted relative to the Declaration of Helsinki. All patients, their parents or guardians, or both provided written informed consent. Statistical Analysis All primary analyses were performed in the intention-to-deal with population.